We examined whether silibinin and resveratrol affect airway mucin production, degradation of $I{kappa}B$ and translocation of NF-${kappa}B$ p65 induced by TNF-${alpha}$ in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-${alpha}$ for 24 h or the indicated periods. The two compounds suppressed TNF-${alpha}$-induced airway mucin production, degradation of $I{kappa}B$ and translocation of NF-${kappa}B$ p65. This result suggests that silibinin and resveratrol can regulate the production of mucin induced by TNF-${alpha}$ through the inactivation of NF-${kappa}B$ pathway in airway epithelial cells.