We carried out flow and structural response analysis of a box-type artificial reef (AR), which is made of concrete and structural steel. From the flow analysis, the wake region and drag coefficient were evaluated and accordingly, the structural analysis was performed to evaluate the stress and deformation of the target reef by considering the pressure field obtained from the flow analysis. The concept of wake volume was presented to quantitatively estimate the wake region and its variation according to flow direction and velocity. From the results, it is shown that the flow responses are only sensitive to the flow direction; the structural responses are sensitive to both of the flow velocity and direction although the magnitudes are negligible; and the wake volume became 3.52 times the AR volume with an optimum installation condition ($30^{circ}$, flow direction) of the target unit.