This study investigates specific fabric structures with the optimal moisture transfer properties of moisture absorbency and dryness depending on the yarn type. Experiments were performed on the moisture absorbency and dryness of yarns with different cross sections (four channels, six channels, and regular round), yarn counts (i.e., denier), filament counts, textures (i.e., textured vs. flat), and structures (e.g., double-layer construction with different densities between the face and back sides). Polyester fiber was identified and determined to fulfill the above functions. Experiments were also performed to determine factors that affect the absorbency function of cotton and polyester microporous spun yarns: the yarn count (mono denier), total yarn denier, absorbent chemical concentration, and yarn cross-sectional shape. Finally, experiments were carried out to compare the moisture absorbency and dryness of different yarn cross sections: four channels, six channels, and regular round.