Urban subways are one of the main parts of urban transportation networks in every city that always requires much attention in order to improve its efficiency in aspects of safety, reliability speed and costs. As the viewpoint of costs, an accurate design, especially design of vertical alignment, can have a dominant role to reduce the costs of urban railway projects. This paper seeks to evaluate the advantages and disadvantages of designing chain vertical alignment for urban subways in compare to flat vertical alignment. To achieve this goal, line A of Qom subway in Iran was selected as a case study in this research. Five parameters considered in the technical-economical evaluation: (1) energy consumption, (2) rolling stock, (3) operation, (4) civil works and geotechnical and (5) hydrological, drainage and pumping. According to the results, a power saving of about 40% have been estimated in the chain vertical alignment for the train without regenerative braking in compare with the flat vertical alignment, although the power saving was calculated less than 10% for the train with regenerative braking. Finally it was found that due to the modern rolling stock technology, the chain vertical alignment represents fewer advantages in compare to the past years.