As the industrial technology has been developed, a dissimilar welding has been received huge attention in various engineering fields. To understand the mechanical properties and possibility of applications of dissimilar metals joining, the laser welding of Cu and Ni dissimilar metals was studied in this paper. Cu and Ni have differences in materials properties, and Cu and Ni make no intermetallic compounds according to typical binary phase of Cu and Ni system. In this study, lap welds of Cu and Ni dissimilar metals using single-mode fiber laser with high welding speed were tried, and mechanical properties of the welds zone were evaluated using a Vickers hardness test and a tensile shear test. To recognize the relation between hardness and tensile shear load, weld fusion zone of interface weld area were observed. And it was confirmed that the ultra-high welding speed could make good weld beads and higher hardness parts had higher tensile shear load under the all conditions.