Purpose: This study was done to identify the effects of Type D personality on compassion fatigue, burnout, compassion satisfaction, and job stress in clinical nurses. Methods: A descriptive cross-sectional design was used. Data were collected from a convenience sample of 172 clinical nurses working in two tertiary hospitals. The structured questionnaires included Type D personality scale, compassion fatigue, burnout, compassion satisfaction, and job stress scales. Results: About 79.7% of participants were classified as Type D personality group. The Type D personality was not related to general characteristics of clinical nurses. The Type D personality group showed statistically significant higher compassion fatigue, burnout, and job stress and lower compassion satisfaction compared to the non-Type D personality group. In addition, compassion fatigue and burnout were positively correlated with job stress and compassion fatigue was positively correlated with burnout. However, compassion satisfaction was negatively correlated with burnout. Conclusion: As the prevalence of Type D personality is high in clinical nurses, it is necessary to assess stress-related personality. In addition, management for the nurse with Type D personality is required to alleviate compassion fatigue, burnout, and job stress and to improve compassion satisfaction.