This paper presents a design optimization for meridional profile and blade angle ${ heta}$ of a centrifugal compressor with DOE (design of experiments) and RSM (response surface method). Control points of the $3^{rd}$ order Bezier curve are used for design parameters and specific overall efficiency is used as object function. The response surface function shows good agreement with the 3D computational results. Three different optimized designs are proposed and compared with reference design at design point and off-design point. Contours of relative Mach number, static entropy, and total pressure are analyzed for improvement of performance by optimization. Off-design performance analysis is conducted by total pressure and efficiency.