In this study, 23 oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. The NF-${kappa}B$ inhibitory activity of the isolated compounds was measured in $TNF{alpha}$-treated HepG2 cells using a luciferase reporter system. Compounds 19-23 inhibited $TNF{alpha}$-stimulated NF-${kappa}B$ activation in a dose-dependent manner, with $IC_{50}$ values ranging from $0.75-8.30{mu}M$. Compounds 19 and 20 also inhibited the $TNF{alpha}$-induced expression of iNOS and ICAM-1 mRNA. Moreover, effect of the isolated compounds on PPARs transcriptional activity was assessed. Compounds 7-11 and 19-23 activated PPARs the transcriptional activity significantly in a dose-dependent manner, with $EC_{50}$ values ranging from $0.9-10.8{mu}M$. These results suggest the presence of potent anti-inflammatory components in P. koreana, and will facilitate the development of novel anti-inflammatory agents.