In This paper, we propose the unsupervised learning and fuzzy logic-based coupled data classification method base on ART. The unsupervised learning-based data classification helps improve the grouping technique, but decreases the processing efficiency. However, the data classification requires the decision technique to induce high success rate of data classification with optimal threshold. Therefore it is also necessary to solve the uncertainty of the threshold decision. The proposed method deduces the optimal threshold with the designing of fuzzy parameter and rules. In order to evaluate the proposed method, we design the simulation model with the GPCR(G protein coupled receptor) data in cloud computing environment. Simulation results verify the efficiency of our method with the high recognition rate and low processing time.