The objective of this study was to optimize ibuprofen loaded nanoemulsion by using a factorial design approach. In the present study attempts have been made to formulate and evaluate nanoemulsion for topical delivery of ibuprofen. Solvent precipitation technique was used for development of ibuprofen nanoemulsion. Miglyol 840 was screened as the oil phase due to a good solubilisation capacity ($0.197{pm}0.012g/mL$) for ibuprofen. On the basis of RHLB of an oil phase Labrasol and Triton X 100 were used as surfactant and cosurfactant, respectively. The study investigated the utility of $2^3$ factorial design for optimization process of nanoemulsion batches. Present model demonstrated the significance of factors such as drug concentration ($X_1$), anti-solvent volume ($X_2$) and surfactant cosurfactant combination concentration ($X_3$) on particle size ($Y_1$) and encapsulation efficiency ($Y_2$). Optimized nanoemulsion showed better flux value (Jss), skin permeation coefficient (Kp) as compared to plain ibuprofen gel. Drug deposition study revealed that optimized ibuprofen nanoemulsion showed deposition of $26.13{pm}3.47{mu}g;cm^{-2}$ in comparison to the deposition of $16.50{pm}2.34{mu}g;cm^{-2}$ shown by plain ibuprofen loaded gel. While the antiinflammatory study has shown faster onset of action with the nanoemulsion which was confirmed by $75{pm}1.27%$ inhibition of inflammation at the end of 1 h and $63.97{pm}1.71%$ at the end of 24 h. The effect of drug was enhanced by prepared nanoemulsion formulation and hence confirms the utility of nanoemulsion system as a vehicle for better topical delivery of ibuprofen.