The principal object of this paper is to study a class of matrix polynomials associated with Humbert polynomials. These polynomials generalize the well known class of Gegenbauer, Legendre, Pincherl, Horadam, Horadam-Pethe and Kinney polynomials. We shall give some basic relations involving the Humbert matrix polynomials and then take up several generating functions, hypergeometric representations and expansions in series of matrix polynomials.