The present study aims to determine the effect of the prevention exercise program of musculoskeletal disorders developed for apple and pear farmers. To achieve this goal, 25 farmers who have subjective symptoms in the musculoskeletal system (Criteria 1 in the National Institute for Occupational Safety and Health) have conducted the prevention exercise program for 12 weeks from April 7, 2011 to July 1, 2011. As a result, the prevention exercise program of the musculoskeletal disorders for farmers in the fruit growing industry have improved physical capability of them (upper extremity endurance, lower extremity endurance, balance and agility) as well as a quality of life effectively. In addition, a quality of life showed a significant correlation with Oswestry Disability Index, and Psychosocial Well-being Index. For the future study, various studies are expected to develop and apply exercise programs in consideration of the characteristics of farming work.