This study is to propose an acceptance model that explains the use of telemedicine effects for chronic disease. For this purpose, the effect factors and variables for Technology Acceptance Model (TAM) were investigated through a structural equation model by performing a sample survey for 210 senior patients who are under treatment with telemedicine in Kangwon area in 2013. The findings from the results are as follows: 1) perceived usefulness and perceived easy of use influence the intent to use telemedicine; 2) open-minded patients group is more positive to the easy of use and usefulness for the telemedicine; 3) it matches with the previous research that shows the trust in telemedicine system is affected by the experience for practical use of information; 4) it is known that the external control factors for health affect perceived usefulness positively. This study contributes to optimize the TAM by verifying the acceptance of telemedicine system in a rural community.