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Effect of excipients on dissolution enhancement of aceclofenac solid dispersions studied using response surface methodology: a technical note
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  • Effect of excipients on dissolution enhancement of aceclofenac solid dispersions studied using response surface methodology: a technical note
  • Effect of excipients on dissolution enhancement of aceclofenac solid dispersions studied using response surface methodology: a technical note
저자명
Kumar. Shobhit,Gupta. Satish Kumar
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2014년|37권 3호|pp.340-351 (12 pages)
발행정보
대한약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The aim of present study was to enhance the dissolution rate of poorly water-soluble drug aceclofenac by solid dispersion technique using corn starch, dicalcium phosphate, lactose, and microcrystalline cellulose as carriers. Solid dispersions were prepared by solvent wetting method using $3^2$ full factorial design for each of the carrier. The prepared solid dispersions were evaluated for differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy (FTIR), and angle of repose. In vitro dissolution studies were carried out in phosphate buffer (pH 7.5) and 0.1 N HCl (pH 1.2). The results of solid state characterization bring to view that in solid dispersions the crystalline drug gets converted to its amorphous form. FTIR study results indicated the absence of interaction between aceclofenac and carriers. For prepared solid dispersions, angle of repose was found to be in the range of $26.19^{circ}$ to $35.29^{circ}$, which indicates good flowability. Enhanced drug dissolution was obtained with carrier in order lactose> corn starch > microcrystalline cellulose > dicalcium phosphate. Hence, these carriers could be used to enhance the dissolution rate of poorly water-soluble drug.