This study aimed to investigate whether silicacerium (III) chloride ($CeCl_3$) nanoparticles could inhibit the formation of advanced glycation end-products (AGEs) and reduce oxidative stress. Silica-$CeCl_3$ nanoparticles were synthesised by adsorption and embedment with micro-silica materials, forming uniform nanoparticles with a diameter of approximately 130 nm. Chaperone activity assays and AGEs formation assays, and intracellular reactive assays were adopted in this study to evaluate $CeCl_3$ nanoparticles effect. UV-visible spectrometry showed that silica-$CeCl_3$ nanoparticles at low concentrations rapidly formed tentatively stable conjugations with ${alpha}$-crystallin, greatly enhancing the chaperone activity of ${alpha}$-crystallin. Moreover, silica-$CeCl_3$ nanoparticles markedly inhibited the fructose-induced glycation of ${alpha}$-crystallin, showing an advantage over the control drugs aminoguanidine and carnosine. Silica-$CeCl_3$ nanoparticles also reduced intracellular reactive oxygen species production and restored glutathione levels in $H_2O_2$-treated human lens epithelial cells. These findings suggest that silica-$CeCl_3$ may be used as a novel agent for the prevention of cataractogenesis.