Purpose: The purpose of this study was to investigate the effects of SP-6 Seoam pellet therapy given to female university students in terms of menstrual pain, menstrual distress, and ADL difficulties. Methods: This study used a pre-test, post-test design with a nonequivalent control group. The participants were 68 female students in two universities. The experimental group(n=34) received Seoam pellet therapy at Sanyinjiao while the control group(n=34) received sham therapy. Data were collected from Sep. 16 to Nov. 30, 2012. Severity of menstrual pain, menstrual distress, and difficulty of ADL were assessed prior to and following treatment. Independent t-test, $x^2$ test, and repeated measures ANOVA were used for examination of group differences using the SPSS/WIN program. Results: Severity of menstrual pain (F=41.09, p<.001), menstrual distress (F=56.31, p<.001), and ADL difficulties (F=46.64, p<.001) showed a significant decrease in the experimental group compared to the control group. Conclusion: Results indicate that this Seoam pellet therapy is effective in reducing menstrual pain, menstrual distress, and difficulty of ADL. Therefore, use of this method is recommended for relief of menstrual pain and menstrual distress through self-care.