The importance of a science park as an instrument of economic development has been realized by developed economies for past three decades. To comprehend the same, developing economies are also planning and implementing science park ventures. However, in terms of planning, science parks are not objects of global consensus because unlike hotel and restaurant chains, which could be planned with similar standards in different regions or countries, there is no single global standard that can be best-fit for science parks. To meet the need for a better understanding of planning, this research studied science parks in developed and developing economies to identify factors that are globally used in this context. This research also extends our knowledge of best practices for growth, governance and sustainability in science parks, and highlights future trends and external factors that may contribute significantly during planning.