This study was aimed to find the impact of science lessons using e-NIE on science process skills and scientific attitudes of elementary students in comparison with that of traditional lessons. Subjects of this study were 5th graders from two separate classes at a elementary school located in U city. And the experiment has been conducted throughout 10 lessons for the duration of total 12 weeks, where one class, experimental group, attended e-NIE based lessons, while the other, comparative group, with traditional lessons for the same period, in an effort to collect both pre and post test results to compare. Findings from this study were briefly listed below: Firstly, e-NIE applied lessons were more effective in improving science process skills than traditional lessons, especially in the domain of integrated science process skills, with meaningful difference. Secondly, lessons combined with e-NIE enhanced scientific attitudes of elementary students more than traditional lessons with meaningful difference.