Objectives: The purpose of this study is to investigate the effects of M&L Self-Growth Meditation Program with Euro QOL-5 Dimension (EQ5D), Five Facet Mindfulness Questionnaire (FFMQ) and psychological test. Methods: 6 middle-age women have participated in the eight weeks of the M&L Self-Growth Meditation Program, and the program was executed once a week for about two hours. We evaluated EQ5D, FFMQ, Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and State-Trait Anger Expression Inventory (STAXI) before and after the program in order to analyze the effects of M&L Self-Growth Meditation Program. Results: 1) EQ5D scores increased significantly (p<0.05), and overall physical condition scale( VAS) increased. 2) In the FFQM scores, value of Nonreactivity increased significantly (p<0.05), and total score increased. 3) Scores of BDI and STAI-S decreased significantly (p<0.05), and STAI-T, STAXI-S, STAXI-T, STAXI-O, STAXI-Su, and STAXI-R decreased. Conclusions: The results suggested that M&L Self-Growth Meditation Program improves the quality of life and mindfulness skill and has a positive responses to psychological problems-depression, anxiety, and anger.