This paper presents the results of an analytical study on seismic reliability of viscoelastically damped frame systems in comparison with that of conventional moment resisting frame systems. In order to exhibit the reliability of the frame systems with viscoelastic dampers, seismic reliability analyses were carried out for steel framed buildings, 5 and 12 storeys in height, designed as: (a) Case 1: Conventional moment resisting frame, (b) Case 2: Frame with viscoelastic dampers providing supplemental effective damping ratio of 10%, and (c) Case 3: Frame with viscoelastic dampers providing supplemental effective damping ratio of 20%. Nonlinear time history analyses were utilized to develop seismic fragility curves whilst monitoring various performance objectives. To obtain robust estimators of the seismic reliability, a database including 15 natural earthquake ground motion records with markedly different characteristics was employed in the fragility analysis. The results indicate that depending upon the supplemental effective damping ratio, frames designed with viscoelastic dampers have considerably lower annual probability of exceedance of performance limit states for structural components, showing up to a five-fold reduction in comparison to conventionally designed moment resisting frame system.