The purpose of this study was to examine the effects of the Mindfulness Meditation program on sleep, depression and quality of life in the institutionalized elderly women. The study was a nonequivalent control group pretest-posttest design. The data was collected from March 7 to April 25 of 2014. Participants in the study were 56 elderly women, 30 institutionalized elderly for the experimental group and 26 institutionalized elderly for the control group. The experimental group received the Mindfulness Meditation program for 90 minutes/session/week for 8 weeks. Data were analyzed using x2-test and t-test for subject homogeneity verification, and paired t-test to examine the hypotheses. Mindfulness Meditation program experimental group showed significant differences in sleep score(t=-4.406, p=<.001), quality of life score(t=-8.799, p=<.001). However no significant differences were found between 2 groups for the scores on depression. According to the results the Mindfulness Meditation program was useful for improving on sleep and quality of life in the institutionalized elderly women.