The spiral up milling of an aluminum alloy was performed in this study. In accordance with the cutting condition, the surface roughness behavior and significance of the research with regard to specific factors were analyzed. The cutting speed, feed, and depth of the cut were found to be statistically significant. A higher cutting speed improved the surface roughness. On the other hand, as the feed and depth of the cut increase, the surface roughness decreases. An interaction effect between the feed and depth of the cut was detected. According to the surface roughness in relation to the cutting conditions, the model showed non-linear behavior.