The purpose of the study was to identify the effect of laser parameters on photocoagulation to maximize safety and efficacy during varicose vein treatment. CW and pulsed modes at 1470 nm were initially compared as a function of power on bovine liver tissue. In the pulsed mode, various parameters including repetition rate, duty cycle, and irradiation time were compared to evaluate tissue response during thermal treatment. The results demonstrated that CW and pulsed modes yielded almost similar coagulation development possibly due to shorter irradiation time of 5 sec. Regardless of laser mode, both repetition rate and duty cycle presented constant coagulation rate whereas longer irradiation time facilitated coagulation process.