Purpose: The purpose of this study was to analyze the effects of empathy, resilience and self-care on compassion fatigue in oncology nurses. Methods: The study design was a descriptive survey and questionnaires were collected from December 1 to 15, 2013. Participants were 171 oncology nurses caring for cancer patients. Data was analyzed using independent t-test, $Scheffacute{e}$ test, one-way ANOVA, Pearson correlation coefficient and hierarchical multiple regression with the SPSS/WIN 18.0 program. Results: Seventy two percent of the participants reported a moderate to high level of compassion fatigue. Empathy was positively correlated with compassion fatigue, whereas, resilience and self-care had negative correlations with compassion fatigue. Finally, empathy, resilience, self-care and age accounted for 30% of the variance in compassion fatigue. Conclusion: Results indicate that empathy, resilience and self-care are factors influencing compassion fatigue. Therefore, it is necessary to develop and make available programs embracing personal factors in the prevention and reduction of compassion fatigue.