In order to satisfy stringent future emission regulation in diesel engines, systematic approaches to mitigate the harmful exhaust emissions were developed, such as engine hardware, fuel injection equipment, engine control, and after-treatment system. In this study, to improve the nano-particle and NOx emissions from a state-of-the-arts diesel engine, effect of various EGR and fuel injection pressure with combustion analysis were evaluated. Size-resolved nano-particle and NOx emissions showed trade-off characteristics with various EGR rate and increment of fuel injection pressure.