Objectives: This study seeks to evaluate the vulnerability assessment of the human health sector for $PM_{10}$, which is reflected in the regional characteristics and related disease mortality rates for $PM_{10}$ in Busan over the period of 2006-2010. Methods: According to the vulnerability concept suggested by the Intergovernmental Panel on Climate Change (IPCC), vulnerability to $PM_{10}$ is comprised of the categories of exposure, sensitivity, and adaptive capacity. The indexes of the exposure and sensitivity categories indicate positive effects, while the adaptive capacity index indicates a negative effect on vulnerability to $PM_{10}$. Variables of each category were standardized by the rescaling method, and each regional relative vulnerability was computed through the vulnerability index calculation formula. Results: The regions with a high exposure index are Jung-Gu (transportation region) and Saha-Gu (industrial region). Major factors determining the exposure index are the $PM_{10}$ concentration, days of $PM_{10}{geq}50$, ${mu}g/m^3$, and $PM_{10}$ emissions. The regions that show a high sensitivity index are urban and rural regions; these commonly have a high mortality rate for related disease and vulnerable populations. The regions that have a high adaptive capacity index are Jung-Gu, Gangseo-Gu, and Busanjin-Gu, all of which have a high level of economic/welfare/health care factors. The high-vulnerability synthesis of the exposure, sensitivity, and adaptive capacity indexes show that Dong-Gu and Seo-Gu have a risk for $PM_{10}$ potential effects and a low adaptive capacity. Conclusions: This study presents the vulnerability index to $PM_{10}$ through a relative comparison using quantitative evaluation to draw regional priorities. Therefore, it provides basic data to reflect environmental health influences in favor of an adaptive policy limiting damage to human health caused by vulnerability to $PM_{10}$.