The purpose of this study was to find the optimal arrangement of FPSO equipment in a module while considering the economic value and fire risk. We estimated the economic value using the pipe connections and pump installation cost in an HP (high pressure) gas compression module. The equipment risks were also analyzed using fire scenarios based on historical data. To consider the wind effect during a fire accident, fuzzy modeling was applied to improve the accuracy of the analysis. The objective functions consisted of the economic value and fire risk, and the constraints were the equipment maintenance and weight balance of the module. We generated a Pareto-optimal front group using a multi-objective GA (genetic algorithm) and suggested an equipment arrangement method that included the opinions of the designer.