This study aimed to develop an approach to accurately predict the wind models and wind effects of large wind turbines. The wind-induced vibration characteristics of a 5 MW tower-blade coupled wind turbine system have been investigated in this paper. First, the blade-tower integration model was established, which included blades, nacelle, tower and the base of the wind turbine system. The harmonic superposition method and modified blade element momentum theory were then applied to simulate the fluctuating wind field for the rotor blades and tower. Finally, wind-induced responses and equivalent static wind loads (ESWL) of the system were studied based on the modified consistent coupling method, which took into account coupling effects of resonant modes, cross terms of resonant and background responses. Furthermore, useful suggestions were proposed to instruct the wind resistance design of large wind turbines. Based on obtained results, it is shown from the obtained results that wind-induced responses and ESWL were characterized with complicated modal responses, multi-mode coupling effects, and multiple equivalent objectives. Compared with the background component, the resonant component made more contribution to wind-induced responses and equivalent static wind loads at the middle-upper part of the tower and blades, and cross terms between background and resonant components affected the total fluctuation responses, while the background responses were similar with the resonant responses at the bottom of tower.