In onshore and offshore plant engineering, a broad use of pipe system have been achieved and accordingly related technologies has been developed especially in the field of flow control valves. The aim of this study is to suggest the quadruple offset butterfly valve for bi-directional applications which show equivalent operating torque characteristics of the triple offset butterfly valve. Seat design parameters for the quadruple offset butterfly valve are determined by the proposed method utilizing both ANOVA (analysis of variance) and the orthogonal array. Through additive model considering the effect of design parameters on seating torque, mean estimation is performed and thus its optimization results are verified by design of experiment results. The insight obtained from the present study is beneficial for valve design engineers to develop reliable and integrated design of the quadruple offset butterfly valve.