Objectives : Pompholyx is a recurrent eczematous skin disease which forms the vesicles on the epidermis of the palms and soles. This study is to find out whether the Sasang Medicine makes any effective treatment of Pompholyx patients. Method : The treatment has been performed to 3 pompholyx patients who came to the clinic and were found to be Taeumin, Soeumin and Soyangin. To verify the effect of treatment, the comparison was made before and after the treatment on the improvement in vesicles, itching, erythema and erosions. Result : The effective treatment results were acquired in all 3 cases of pompholyx patients when Sasang Medicine was performed for the treatment of them. Conclusions : The Sasang medicine would be likely to be effective in treatment of pompholyx or a recurrent eczematous skin disease in the future.