IC 10 is one of the most well-known irregular starburst dwarf galaxies in the Local Group. Its low metal and oxygen abundance together with proximity make it an excellent laboratory to test star formation models, especially in low-metallicity systems like galaxies in the early Universe as well as many other local dwarfs. Among a number of active star forming regions, we have detected H2O kilo-maser emission in the south-east region of IC 10(IC 10 SE) using the Korean VLBI Network(KVN). This maser line is likely to be associated with a giant molecular cloud identified in IC 10 SE by former CO studies. Using the HI and CO data from the VLA and SMA archive, we probe the atomic and molecular gas properties of IC 10 SE. We discuss how the cool gas morphology and kinematics are related with maser and star formation activity in IC 10 SE.