Currently, computer-aided technology becomes one of main issues in clinical dentistry. About 25 years ago, the development of dental CAD/CAM systems for the fabrication of crowns and fixed partial dentures leads to be able to fabricate complete denture today. The fabrication of milled complete denture prostheses with digital scanning technology may decrease the number of patient appointments. However, the precise tooth arrangement and evaluation by patient is not promising relatively. The purpose of this review was to analyze the existing literature on computer aided technology for fabricating complete denture with historical background, current status, and future perspectives. In addition, two available commercial systems were introduced.