In this letter, we propose an efficient near-optimal detection scheme (that makes use of a generalized sphere decoder (GSD)) for blind multi-user multiple-input multiple-output (MU-MIMO) systems. In practical MU-MIMO systems, a receiver suffers from interference because the precoding matrix, the result of the precoding technique used, is quantized with limited feedback and is thus imperfect. The proposed scheme can achieve near-optimal performance with low complexity by using a GSD to detect several additional interference signals. In addition, the proposed scheme is suitable for use in blind systems.