Recently, the in-wheel motor vehicle is rapidly developed to solve energy exhaustion and environmental problems. Especially, it has the advantage of independently driving the torque control of each wheel in the vehicle. However, due to the weight increase of wheel, the comfort of vehicle riding and performance of road holding become worse. In this paper, to compensate the poor performance, a simultaneous control of the driving torque and semi-active suspension system is investigated. A vehicle model is generated using CarSim Software and validated by field tests. Co-simulation of CarSim and MATLAB/Simulink with control logics is carried out, and it is found that simultaneous control of the driving torque and semi-active suspension system can improve driving stability and durability of the in-wheel motor system.