Purpose: The aim of this methodological study was translation and adaption of the evidence based guideline of the RNAO in Canada, for screening of delirium, dementia and depression in older adults. Methods: The guideline adaptation process was conducted according to the standardized methodology for nursing practice guideline adaptation developed by Korean Hospital Nurses Association. Quality of the RNAO guideline was evaluated using AGREE II tool. Then the guideline was translated into Korean and a preliminary guideline was established after appropriateness and applicability were checked by an expert group. Results: The adapted screening practice guideline consisted of 3 domains and 11 recommendations, including practice, education, organization and policy. Of the recommendations 9.1% were graded A, 27.3%, B, and 63.6%, C. Conclusion: This guideline is expected to contribute to improving nursing quality by offering it as a guide to evidence based practices for screening delir-ium, dementia and depression in Korean older adults.