In this paper, the driving force of Korea economic growth is the competitive edge of many global leading manufacturing companies which are leading world. In manufacturing industry, one of the key technology power can be Smart Factory System. Through implementation of Smart Factory System it is possible that digital verification and simulation of prior plant construction, streamline of production, process innovation and efficiency, quality improvement, set up of global collaboration, integration of total process, and innovation management, which are differentiate strategy. Most manufacturing have implemented the Smart Factory System which can reduce the production cost as well as plant construction cost, as the strategy of Design for Manufacturing. The purpose of this paper is to study how to increase the competitiveness and make differentiation by the analysis of cases which have implemented the Smart Factory System.