The purpose of this study is to provide students with basic data for proper stress management and adaptation to school life by checking the stress factor and stress coping method of students. The purpose of this study was to investigate 260 occupational therapy departments students which two university located in Chungcheong and Jeonla provinces from September 19, 2016 to October 30, 2016. The results of this study are as follows: The stress of relationship with lover (12.22 ± 5.90) and the stress of relationship with professor (14.43 ± 6.16) was higher in the 4th grade (P <.05). Score of the career problem (27.18±5.42), the value problem (13.76 ± 4.53), the academic problem (23.98 ± 5.24) and total score of stress of facing problem (81.51±16.25), are also higher in the 4th grade (P <.05). When we look at the stress difference according to the types of stress coping, it can be confirmed that the type of solving through emotional control (hobbies) is tend to get a low stress than the others. The students in the occupational therapy department are more stressed as the grade goes up, so the higher the grade, the more stress management is needed. It is also important to help students to cope with stress in an active attitude.