최근 노인인구의 증가와 함께 osteoporosis, breast cancer, prostate cancer 환자군에서 bisphosphonate의 사용이 늘어나고 복용이 장기화되면서 Bisphosphonate Related Osteo Necrosis of Jaw (BRONJ)의 발생이 많이 보고되고 있으며 특히 골괴사의 위험 요인과 유발 요소에 대한 연구가 많이 이루어지고 있다. 이중 경구 bisphosphonate를 복용한 환자에서의 BRONJ 발병 위 험도는 정주 bisphosphonate를 복용한 경우에 비하여 훨씬 낮으며 2009년 AAOMS에 의하면 대략 0.01∼0.06%로 보고되었다1). 또 2010년 Lo 등은 경구로 복용한 환자들 중 약 0.1% (8,572명 중 9명)에 서 골괴사가 발생하였음을 보고하였다2).
Osteonecrosis of the jaw is a serious complication among patients receiving bisphosphonate therapy. Recently, numerous cares of BRONJ have been reported because of increasing the olders, however methods for early detection and identification of patients at risk for osteonecrosis of the jaw need further investigation. Most of reports state that tooth extraction is the most commom event for triggering factor of BRONJ. Information about association of dental implant with the development of BRONJ in patients with oral bisphosphonate therapy is scarce. A 76 years-old woman was referred by local dental clinic for gingiva inflammation, pus discharge, necrotic bone were observed in Rt. mandible after dental implant installation. We perfomed surgical procedure as segmental osteotomy, partial mandibulectomy under general anesthesia . In this paper, we report the treatment method and prognosis of BRONJ in patient receiving dental implant with the review of literature. (JOURNAL OF DENTAL IMPLANT RESEARCH 2012;31(2):61-65)
서론 증례보고 고찰 REFERENCES
