This study examines the concepts of counter-act against the Bio-terrorism and the reaction system in advanced countries, thereby to find out reaction system necessary to Korea. Acts on anti-Bio-terrorism is divided to detection stage, protection stage, diagnosis stage and detoxication and neutralization stage according to flow of event occurrence. As for detection stage, Korea is developing it as contact type, while advanced countries are under development of the devices that may detect the terrorism from the remote distance. It is necessary for Korea to develop the remote-distant detection system as well as the contact type of device that may promptly operate. Among the protection gears, the quality of Korea\'s gas mask is recognized worldwide, but that of other outfits should be improved by applying the state-of-art science technology. The diagnosis device also should be developed to the extent that the dispatched initial action team may make immediate decisions necessary in the field. As the current trends for detoxication materials worldwide require the improvement to new materials harmless to human body and equipment, Korea is also required to acquire those materials. The technology for neutralization means the development of vaccine and antibiotics and it requires the development made by shared efforts worldwide. For this purpose, it is necessary to further develop Korea\'s medical technology. In addition, the further efforts are required in terms of reaction manual, training model, public communication efforts and preparation for trauma syndrome.