The main purpose of this study was to explore various job stress factors perceived by teachers of gifted students. In addition, the present study was to find out the role of job stress and teacher efficacy of teachers of gifted students on their creative teaching activities as well as the relationship among these factors. For this purpose, 183 teachers of gifted students participated. Results were as follows: First, this study developed an instrument to measure gifted education teachers' job stress, and it was composed of 27 questions in 4 factors which were 'gifted education teacher's role identity', 'management of curriculum and instruction for the gifted', 'support and reward system for teaching the gifted', 'personal relationship related to gifted education'. Second, multiple regression analysis was done to find out the effects of job stress and teacher efficacy on creative teaching activities of the gifted education teachers. Gifted education teachers' job stress, especially 'gifted education teacher's role identity' factor, was negatively related to the creative teaching activities. Third, teacher efficacy did not show any moderating effect, but revealed partial mediating effect between job stress and creative teaching activities, utilizing the Baron and Kenny's three step multiple regression analysis. Implication of the study related to the gifted education was discussed in depth.