The effects of saponin and histamine solution on the division of Saccharomyces cerevisiae were compared with the effects of ginseng on the division. 1. 10^-2, 10^-3% saponines were inhibitory on the division but 10^-5% saponin increased slightly the division, however its increasing rate was much less than that of ginseng. 2. 0.5% histamine was inhibitory on the division but 10^-2% histamine increased the division, however its increasing rate was higher than that of saponin and lower than that of ginseng. 3. Although some doses of saponin and histamine were inhibitory on the division, the increasing dose of saponin or histamine on the division could be recognized as shown in the case of the optimal dose of ginseng.