Electromyographic analysis was made in the forearm to clarify the prime mover of the wrist joint in flexion and extension. Loads of 5 and 10 pounds were given to the hand during isometric and isotonic contraction. The results of this study were summarized as follows: 1) M. flexor carpi ulnaris and m. extensor carpi radialis acted as the prime mover during flexion and extension, respectively, of the wrist joint. 2) The flexor and the extensor of the forearm showed synergistic activities under isotonic contraction, but under isometric contraction the flexor only acted. 3) Muscular activity during the isotonic contraction slightly increased compared with the isometric contraction. 4) EMGs and integrated EMGs were somewhat enhanced as the load increased, but there was no significant difference between 5 and 10 pounds load.