The experimental rabbits were infested with 300 of metacercariae of Clonorchis sinensis. The therapeutic effects of following 6 kinds of hexachlorophene derivatives on infected rabbits were compared with those of hexachlorophene and 2,2-methylenebis (3,4,6-trichlorophenoxy acetic acid) (MTPA). The drugs were medicated by mouth for 7 days after infection of 40 days, and the following results were obtained. 1) The therapeutic effects of following four hexachlorophene derivatives are less potant than those of hexachlorophene and MTPA. 2) Among hexachlorophene derivatives, 2,2-methylenebis (3,4,6-trichlorophenoxy benzoylate) and 2,2-methylenebis (3,4,6-trichlorophenoxy β-ethly alcohol) are more effective than 1,1-dihydroxy ethyl ether, 2,2-methylenebis (3,4,6-trichlorobenzene) (Table 1).