The effects of dephenylhydantoin, strychnine, coramine, d-amphetamine and chlorpromazine on Qo2 and non-inulin space Na+, K+ concentration of rat cerebral cortical slices incubated in pH 7.4 glycylglycine glucose saline was investigated. In general, there are decreased non-inulin space Na+ concentration or increased non-inulin space K+ concentration or both when the ratio of respiration to non-inulin space is greater than control group except in case of chlorpromazine 10-4 M. And it is suggested that the ratio of respiration to non-inulin space is responsible more closely for the non-inulin space Na, K concentration than Qo2 expressed per tissue wet weight. Effects of diphenylhydantoin and several other agents on electrolytes and the electroshock seizure threshold are discussed.
