The purpose of this study was to provide important data for development on job stress therapy of care-givers. The data collection, for 56 days from August 10th to October fifth, 2006, was done at the three general hospitals, located in K, Seoul and Busan city. The subjects were 124 persons who were Buddhism and belonged on association of care-givers in Buddhism. For measuring of job stress of care-givers, the questionnaires, developed by Kim (2006) and revised by reseacher was used. Data were analyzed by the t-test, one-way ANOVA and Cronbach’s value was calculated for the instrument’s credibility using SPSS program 12.0/pc+. The result of this study were as follows: 1. In differences of level of job stress according to demographic characteristics, working period in care-giver (F=2.464, P <.05), marital status(F=3.226, P <.05), monthly income (F=4.572, P <.01), overloads in living costs(F=3.886, P <.05) and the level of experience in stress related to religious problems(F=4.573, P <.01) were statistically significant differences. 2. In differences of level of job stress according to the religious life on Buddhism, Buddhism faith(F=4.271, P <.01), the level of helping of religious life on Buddhism in care-giver’s life(F=3.521, P <.05), the things for helping in reliving job stress(F=4.582, P <.01) and the level of helping in reliving job stress of a meditation and prayer(F=5.320, P <.01) were statistically significant differences. The results of this study, the religious life on Buddhism should be considered in order to reliving and prevention the job stress of care-givers.