Objectives: This study was designed to investigate the correlation between Sasang constitution and dyslipidemia and the possibility that Sasang constitution can be a risk factor of dyslipidemia. Methods: This study was a retrospective cross-sectional study based on chart review. Seventeen thousand sixty-nine charts which were collected from May 2007 to June 2010 in International Healthcare Service Center, Kyung Hee University Medical Center, were reviewed for the study. Fifteen thousand two hundred fifty charts including Sasang constitutional diagnosis and lipid profiling were selected and we examined the correlation between Sasang constitution and dyslipidemia. Results: After adjusted for body mass index, the levels of total cholesterol and triglyceride were highest in Taeeum group, and lowest in Soeum group. High-density lipoprotein was highest in Soeum group, and lowest in Taeeum group. After adjusted for age, sex, and body mass index, theodds ratios for ‘high triglyceride’ were 1.716 (1.411∼2.087) in Soyang group and 2.021 (1.650∼2.475) in Taeeum group compared to Soeum group. The odds ratio for ‘high low-density lipoprotein’ was 1.229 (1.006∼1.501) in Soyang group compared to Soeum group. The oddsratios for ‘low high-density lipoprotein’ were 1.195 (1.033∼1.381) in Soyang group and 1.414(1.212∼1.649) in Taeeum group compared to Soeum group. Conclusions: The lipid profiles and dyslipidemic risk differed across constitutional types, showing constitution type-specific patterns, so that we could infer the possibility that Sasang constitutional types can be a risk factor of dyslipidemia.