Purpose & Methods: In order to study obese gene mutation rate in obese Korean patients and to investigate the effect of Chegamuiyiin-tang and electro-lipolysis-acupuncture on obesity treatment, the difference of the reaction to herbal dieting between patients with β3 adrenergic receptor mutation and the patients with wild type β3 adrenergic receptor is observed. Results: Chegamuiyiin-tang and electro-lipolysis-acupuncture treatment are effective on the treatment of obesity in weight reduction, body fat reduction and the circumferences of arm, abdomen, hip and thigh. In the comparison of β3 adrenergic receptor wild type and β3 adrenergic receptor mutation groups, body fat was more reduced with statistical significance, and as for BMI change and body weight change were higher in β3 adrenergic receptor mutation groups with no statistical significance. In the comparison of β3 adrenergic receptor wild type and β3 adrenergic receptor mutation groups among BMI under 25 patients, change rate of body weight, BMI, body fact percentage, WHR and body circumference were higher in β3 adrenergic receptor mutation group than in β3 adrenergic receptor wild type group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body weight and body fat in β3 adrenergic receptor mutation group than wild type group, and that the earlier the treatment is applied, the more effective it is.