The aim of this study was to the effect of very low calorie diet with Chegameuiintang to treat obese patients. Methods: We have evaluated 54 obese patients during very low calorie diet with Chegameuiintang weight-reducing regime by determining the body composition before and 1 month, 2 months after treatment by Bioelectrical impedence analysis. Results: In the change of body composition by the treatment, mean weight reduction was 11.59kg(15.57% of initial weight), mean weight reduction after 1month was 7.68kg( 10.31% of initial weight), mean weight reduction after 2 months was 3.91kg(5.86% of weight after 1 month). Mean reduction in total fat mass was 8.03kg(29.14% of the initial fat mass) which constitutes 69.28%. Mean reduction in lean body mass was 3.56kg(7.59%). Conclusions: This study has demonstrated that the compound therapy of very low calorie diet and Chegameuiintang(Tiganyiyiren-tang) is the good way of weight reduction, which reduces total fat mass and preserves lean body mass.