Purpose: Recently, researchers at medical schools have shown increasing interest in developing a curriculum for medical humanities and improving ‘humanity’ in existing curriculums. This study introduces the process of developing the ‘doctor & leadership’curriculum at K University from 2002. The results of the three-year implementation were analyzed. The effectivenessof the curriculum development is discussed. Methods: The curriculum development followed the ADDIE model. A sixteen-week curriculum with three subjects was developed. The main methods of instruction were self-regulation learning and collaboration learning. The instruction method was a blended learning approach composed of both on-line and off-line instructions. Students were assessed through a portfolio assessment. ‘Leadership self-assessment’ and ‘satisfaction index of the overall curriculum were measured. Results: The results on pre- and post- leadership self-assessment shows that leadership increased significantly after the learning process. Of the 4 sub-factors of the satisfaction index, the satisfaction indices on the blended learning, professor-student interaction, and instruction design had the greatest influence on the total satisfaction index (p<.001) Conclusion: Our outcome indicates that the ‘doctor & leadership curriculum is significantly effective. And generally, to increase the satisfaction index of courses, collaboration learning based on team projects and blended learning, as well as, professor-student interaction are helpful in encouraging the application of skills.