Purpose: To establish a medical informatics curriculum for premedical students. Methods: The author conducted a questionnaire survey on 202 second year premedical students from two medical schools, one in Seoul and one in Asan. The chi-square test was used to do a statistical analysis comparison of the results from these two school groups. In addition, the reliability test was used for the questionnaire s reliability. Results: The results of the survey show that computer skills in second year premedical students differ by gender. The results also indicate that differences exist between the two schools, as the curriculums of the freshman year differ between the schools. Moreover, it is observed that more than 60 percent of the subjects have difficulties dealing with complicated problems such as fixing or replacing hardware. Conclusion: The survey was conducted to assess the level of computer skills in premedical students at two medical schools. Through careful analysis of this survey, we were able to define the necessary level of computer skills required in premedical students in the Medical Informatics curriculum.